There were a couple published studies in the last few years about ceramide levels in people with CF being either too high or too low. I didn’t know what to make of it but I now see that the drug Fenretinide is being moved forward and has received orphan drug status. This drug increases the number of ceramide species, thought to be deficient in CF, and this in turn boosts the ability to fight off pseudomonas infections in the CF lung. In theory anyway.
It looks very promising based on the mice studies but we all know mice are not the best model for CF.
‘Orphan Drug’ Research Offers Hope.